# Glutamate dehydrogenase: A study of its physico-chemical properties from the liver of mice of two different age groups

Abstract

Glutamate dehydrogenase (GDH) an enzyme which catalyze the reversible formation of glutamate from $\alpha$-ketoglutarate, occupies a central position in mammalian nitrogen metabolism since the reaction which it catalyze provides the major pathway by which ammonia become bound to the $\alpha$-carbon atom of an $\alpha$-ketoacid to generate glutamate. The activity of GDH is influenced by a number of physical and chemical parameters that contributes to its stability as well as its activity. Physico-chemical studies of partially purified GDH from two age groups (10- and 90-day old), from the mice liver tissue are reported.

Keywords GDH, physico-chemical, mice